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Emerging role of RUNX3 in the regulation of tumor microenvironment

Sarala Manandhar1, You Mie Lee1

  • 1Laboratory of Vascular Homeostasis Regulation, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu 41566, Korea.

BMB Reports
|February 13, 2018
PubMed

Insights

Cancer relapse remains a challenge, but the tumor microenvironment offers potential solutions. RUNX3, a transcription factor, is a key regulator in hypoxic and immune-infiltrated tumors, suggesting new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Immunology

Background:

  • Cancer therapeutic targeting faces challenges due to relapse.
  • The tumor microenvironment (TME) significantly influences cancer progression and malignancy.
  • Runt domain transcription factors (RUNX1, 2, and 3) are crucial in development and disease.

Purpose of the Study:

  • To review the impact of hypoxia and immune cell infiltration in the TME.
  • To highlight RUNX3 as a critical regulator within the TME.
  • To propose therapeutic interventions targeting RUNX3 for cancer management.

Main Methods:

  • Literature review focusing on hypoxia, immune cells, and RUNX3.
  • Analysis of the functional roles of RUNX3 in the TME.
  • Synthesis of current knowledge to suggest therapeutic strategies.

Main Results:

  • Hypoxia and immune cell infiltration are common in tumors.
  • RUNX3 plays a critical role in regulating the TME under these conditions.
  • Understanding RUNX3's function provides insights into tumor growth and malignancy.

Conclusions:

  • RUNX3 is a key regulator influenced by hypoxia and immune cells in the TME.
  • Targeting RUNX3 presents a potential therapeutic avenue for managing cancer growth and malignancy.
  • Further research into RUNX3's role can lead to effective cancer treatments.

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