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The blood pressure decrease-induced sympathetic discharge following atrial natriuretic factor administration may

O Kuchel, R Garcia, W Debinski

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |September 1, 1986
    PubMed
    Summary
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    Atrial natriuretic factor (ANF) lowers blood pressure in SHR rats but not WKY rats. ANF increases sodium excretion in WKY rats by reducing sympathetic tone, an effect overridden by reflex sympathetic activity in SHR rats.

    Area of Science:

    • Cardiovascular Physiology
    • Renal Physiology
    • Endocrinology

    Background:

    • Atrial natriuretic factor (ANF) is a hormone involved in regulating blood pressure and sodium balance.
    • Hypertension in Spontaneously Hypertensive Rats (SHR) is associated with altered sympathetic nervous system activity.
    • Wistar-Kyoto (WKY) rats serve as a normotensive control model.

    Purpose of the Study:

    • To investigate the effects of ANF infusion on blood pressure, sodium excretion, and urinary catecholamines in conscious SHR and WKY rats.
    • To elucidate the role of the renal sympathetic nervous system in mediating the actions of ANF.

    Main Methods:

    • Conscious SHR and WKY rats were infused with ANF (Arg 101-Tyr 126) for 7 days using miniosmotic pumps.
    • Basal blood pressure, sodium excretion, and urinary catecholamines were measured and compared between ANF-infused and sham-infused groups.

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    Main Results:

    • ANF infusion significantly reduced blood pressure in SHR rats (from 181 mmHg to 137 mmHg).
    • No significant blood pressure change was observed in ANF-infused WKY rats.
    • WKY rats showed increased sodium excretion and a higher urinary dopamine/norepinephrine ratio, indicating reduced sympathetic tone.
    • SHR rats did not exhibit these changes in sodium excretion or catecholamine ratios.

    Conclusions:

    • ANF's hypotensive effect in SHR may be counteracted by a reflex increase in sympathetic activity, overriding its natriuretic potential.
    • In WKY rats, ANF-induced withdrawal of renal sympathetic tone facilitates natriuresis.
    • The dissociation between ANF's hypotensive and natriuretic effects in vivo is influenced by secondary sympathetic responses.