Related Experiment Video
Updated: Feb 14, 2026

Dural Stimulation and Periorbital von Frey Testing in Mice As a Preclinical Model of Headache
Published on: July 29, 2021
[Chronic post-dural headache secondary to meningitis]
Andreas Ravn1, Louise Feldborg Lyckhage, Rigmor Høland Jensen
1ravn.med@gmail.com.
A young man with viral meningitis developed a persistent, position-dependent headache. Diagnosis of post-dural puncture headache was confirmed, and while an epidural blood patch initially helped, subsequent treatments failed, highlighting the need to recognize orthostatic headache components.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Viral meningitis can present with various neurological complications.
- Headaches are a common symptom, but persistent, orthostatic headaches require further investigation.
Observation:
- A young male patient presented with fever and headache, diagnosed with viral meningitis.
- Post-discharge, he developed a persistent headache exacerbated by an upright position.
- This positional headache was initially attributed to the meningitis.
Findings:
- The patient was diagnosed with post-dural puncture headache (PDPH) 14 months after initial presentation.
- An initial epidural blood patch (EBP) provided temporary relief.
- Repeated EBP treatments were ultimately unsuccessful in resolving the headache.
Implications:
- This case underscores the importance of identifying and evaluating orthostatic symptoms in patients with persistent headaches.
- Recognizing PDPH, even months after an initial event, is crucial for appropriate management.
- The limitations of repeated EBP in refractory cases warrant consideration of alternative or adjunctive therapies.
Related Concept Videos
Cranial and Spinal Meninges
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Secondary Active Transport
Secondary Active Transport
Secondary Healthcare System
Primary and Secondary Growth in Roots and Shoots
Secondary Distribution
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...

