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Updated: Feb 14, 2026

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
13:50

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Published on: June 11, 2011

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Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients

L V Gómez-Santana1, A C Torre1, B A Hernández1

  • 1Servicio de Dermatología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Actas Dermo-Sifiliograficas
|February 13, 2018
PubMed

Insights

Histoplasmosis, a fungal infection, can cause severe respiratory or disseminated disease. Diagnosing Histoplasma capsulatum via skin lesions in HIV-negative patients is crucial for timely treatment.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Dermatology

Background:

  • Histoplasmosis is a systemic mycosis caused by Histoplasma capsulatum.
  • Infection typically occurs via respiratory inhalation of microconidia.
  • Primary infection is often asymptomatic, but severe respiratory or disseminated forms can develop.

Observation:

  • Disseminated histoplasmosis can manifest with mucocutaneous lesions in immunocompromised individuals.
  • This report details three HIV-negative patients with Histoplasma capsulatum infection.
  • Diagnosis was significantly aided by the presence of characteristic skin lesions.

Findings:

  • Skin manifestations were key to identifying Histoplasma capsulatum infection.
  • Early diagnosis through cutaneous lesions facilitated prompt treatment initiation.
  • The study highlights the diagnostic importance of mucocutaneous findings in non-HIV-associated histoplasmosis.

Implications:

  • Recognizing skin lesions as diagnostic markers can improve histoplasmosis management.
  • This approach is particularly relevant for HIV-negative patients presenting with disseminated disease.
  • Early diagnosis and treatment of histoplasmosis can prevent severe complications.
Keywords:
Cutaneous histoplasmosisDisseminated histoplasmosisHistoplasmosis cutáneaHistoplasmosis diseminadaImmunosuppressionInmunosupresiónItraconazolItraconazole

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