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Normal saline for intravenous fluid therapy in critically ill patients
Fei-Hu Zhou1, Chao Liu1, Zhi Mao1
1Department of Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi
|February 13, 2018
Summary
Normal saline (NS) may reduce acute kidney injury (AKI) compared to 6% hydroxyethyl starch (HES) in critically ill patients. However, NS showed no significant difference in mortality or AKI versus other fluids.
Area of Science:
- Critical Care Medicine
- Nephrology
- Fluid Therapy Research
Background:
- The optimal intravenous fluid for critically ill patients is debated.
- Normal saline (NS) is commonly used but its safety and efficacy are questioned.
Purpose of the Study:
- To review randomized controlled trials (RCTs) comparing NS with other fluid solutions in critically ill patients.
- To evaluate the impact of NS on acute kidney injury (AKI) and mortality.
Main Methods:
- Systematic review of randomized controlled trials (RCTs).
- Comparison of normal saline (NS) against 6% hydroxyethyl starch (HES), 10% HES, albumin, and buffered crystalloid solutions.
- Analysis of outcomes including acute kidney injury (AKI) and mortality.
Main Results:
- Normal saline (NS) may decrease the incidence of acute kidney injury (AKI) when compared to 6% hydroxyethyl starch (HES).
- No significant differences in mortality or AKI incidence were observed between NS and 10% HES, albumin, or buffered crystalloid solutions.
Conclusions:
- Fluid therapy choice in critically ill patients requires individualized assessment.
- Normal saline (NS) presents a potentially safer option regarding AKI compared to certain HES solutions.
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