Related Experiment Video
Updated: Feb 14, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
Published on: February 7, 2025
Pediatric Stroke and Its Mimics: Limitations of a Pediatric Stroke Clinical Pathway
Amy M DeLaroche1, Lalitha Sivaswamy2, Ahmad Farooqi3
1Division of Emergency Medicine, Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan.
Insights
Pediatric stroke protocols expedite care but do not reliably distinguish stroke from mimics. Further research is needed to develop a reliable pediatric stroke screening tool.
Area of Science:
- Pediatric Neurology
- Emergency Medicine
Background:
- Acute stroke protocols aim to improve care delivery for pediatric stroke.
- It remains unclear if these protocols can differentiate stroke from stroke mimics in children.
Purpose of the Study:
- To describe institutional experience with stroke mimics identified via the Pediatric Stroke Clinical Pathway (PSCP).
Main Methods:
- The PSCP was implemented in a Level 1 pediatric emergency department for children aged 1 month to 18 years.
- Demographic and clinical data were compared for patients diagnosed with stroke versus stroke mimics between June 2014 and December 2016.
Main Results:
- Of 59 children evaluated, 14 had stroke and 45 had stroke mimics.
- Common mimics included functional neurological disorders, transient neurological deficits, migraine, and seizure.
- Vomiting was more common in stroke patients, but demographics and neuroimaging times did not differ; physical examination findings were similar.
Conclusions:
- The PSCP ensures timely evaluation but does not reliably differentiate pediatric stroke from mimics.
- Multicentered studies are required to develop a "stroke screen" for accurate differentiation.
Background:
Acute stroke protocols improve delivery of care but it is unclear whether these resource intensive protocols are able to differentiate stroke from mimics in children. The aim of this study is to describe our institution's experience with stroke mimics identified through our pediatric stroke clinical pathway (PSCP).
Methods:
The PSCP was implemented in our level 1 pediatric emergency department in June 2014 for children aged one month to 18 years. For patients managed using the PSCP from June 2014 to December 2016, demographic and clinical data were compared for patients diagnosed with stroke or a stroke mimic.
Results:
A total of 59 children were evaluated with the PSCP. Fourteen children were identified as having a stroke and 45 children had stroke mimics. The most common stroke mimics were functional neurological disorders (20.0%), transient neurological deficits (17.8%), migraine (15.6%), and seizure (11.1%). Patient demographics and time to neuroimaging did not differ between patients with and without stroke. Vomiting was commonly reported by patients with stroke (odds ratio: 4.00, 95% confidence interval: 1.12 to 14.35), whereas weakness was not (odds ratio: 0.7, 95% confidence interval: 0.07 to 0.90), but the physical examination did not differ between patients with and without stroke.
Conclusions:
The PSCP ensures timely evaluation of patients presenting with neurological deficits but fails to reliably differentiate between patients with stroke and patients with stroke mimics. Further multicentered studies are needed to develop a "stroke screen" that reliably distinguishes pediatric stroke from its mimics.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Cardiac Output and Stroke Volume
In an average resting adult male, the typical cardiac...

