THz imaging system for in vivo human cornea

Area of Science:

• Biomedical Optics
• Medical Imaging
• Terahertz Technology

Background:

• Corneal tissue water content (CTWC) is crucial for diagnosing corneal diseases.
• Current Terahertz (THz) imaging methods face challenges with data interpretation due to contact-based imaging.
• A non-contact approach is needed for accurate CTWC assessment.

Purpose of the Study:

• To develop a novel non-contact THz imaging system and reconstruction methods for human cornea.
• To accurately measure corneal tissue water content (CTWC) in a non-contact manner.
• To enable early and accurate detection of corneal diseases.

Main Methods:

• Developed a novel imaging system using a 650 GHz multiplier source and Schottky diode detector.
• Implemented advanced image reconstruction methods tailored for nearly spherical targets like the cornea.
• Validated the system using characterization targets, corneal phantoms, and ex vivo corneas.

Main Results:

• The novel system demonstrated hydration sensitivity and reliable CTWC measurement.
• Resolution and imaging field strength correlated well with theoretical predictions.
• Successful non-contact THz imaging of in vivo human cornea was achieved.

Conclusions:

• The developed non-contact THz imaging system shows promise for clinical application.
• This technology can facilitate early diagnosis and study of corneal diseases.
• Further optimization of the system design is discussed for clinical use.