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Updated: Feb 14, 2026

Intranuclear Microinjection of DNA into Dissociated Adult Mammalian Neurons
Published on: December 10, 2009
A case of neuronal intranuclear inclusion disease associated with lupus nephritis-like nephropathy
Taro Horino1, Tatsuki Matsumoto1, Kosuke Inoue1
1Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, Japan.
Abstract:
Neuronal intranuclear inclusion disease (NIID) is a relatively new entity identified as a progressive neurodegenerative disease characterised by eosinophilic hyaline intranuclear inclusions widely observed in neuronal and somatic cells. Renal biopsy from one of our patients with NIID showed lupus nephritis-like pathology. He was treated with steroids and angiotensin-converting enzyme inhibitors and his proteinuria improved. The present case highlights that immune-mediated glomerulonephritis can be a presenting feature of NIID, which can be controlled with proper treatment.
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