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Related Experiment Videos

Lipomatoses.

Philipp Al Ghazal1, Lisa-Lena Grönemeyer1, Michael P Schön1,2

  • 1Department of Dermatology, Venerology and Allergology, University Medical Center, Göttingen, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|February 13, 2018
PubMed
Summary

Lipomatoses are benign adipose tissue growths, with benign symmetric lipomatosis (BSL) being the most common type. While causes are unclear, treatments focus on symptom relief through surgery or temporary lidocaine infusions.

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Area of Science:

  • Endocrinology
  • Dermatology
  • Genetics

Background:

  • Lipomatoses are benign adipose tissue proliferations with characteristic distribution patterns.
  • Unlike circumscribed lipomas, they grow diffusely and lack a fibrous capsule.
  • Benign symmetric lipomatosis (BSL), or Launois-Bensaude syndrome, is the most common form, with subtypes based on adipose tissue distribution.

Purpose of the Study:

  • To review the characteristics, etiology, and management of lipomatoses.
  • To differentiate BSL from lipomatosis dolorosa.
  • To highlight current therapeutic limitations and outcomes.

Main Methods:

  • Literature review of lipomatoses, focusing on BSL and lipomatosis dolorosa.
  • Analysis of potential etiological factors including genetics, alcohol consumption, and mitochondrial dysfunction.

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  • Evaluation of reported therapeutic interventions and their efficacy.

    • Main Results:

    • The etiology and pathogenesis of lipomatoses remain largely unknown, with potential links to hereditary factors, alcohol use, and mitochondrial issues.
    • BSL presents with four distinct subtypes based on adipose tissue distribution.
    • Lipomatosis dolorosa, primarily affecting middle-aged women, is associated with severe pain and requires consideration of comorbidities like depression.

    Conclusions:

    • Effective drug therapies for lipomatoses are lacking; surgical interventions can alleviate symptoms but recurrence is possible.
    • Repetitive lidocaine infusions may offer temporary relief for lipomatosis dolorosa.
    • Further research is needed to elucidate the pathogenesis and develop evidence-based treatments.