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Iridium(I)-Catalyzed Alkylation Reactions To Form α-Alkylated Ketones
Sertaç Genç1, Salih Günnaz1, Bekir Çetinkaya1
1Chemistry Department, Ege University , Bornova, 35100 Izmir, Turkey.
Abstract:
A highly effective and green procedure for the formation of α-alkylated ketones has been disclosed via the reaction of primary alcohols with secondary alcohols and ketones by using [IrCl(COD)(NHC)] complexes as a catalyst. Various α-alkylated ketones were obtained in high yields from the alkylation of alcohol with alcohol and ketone with alcohol through a borrowing hydrogen reaction by using 0.05-0.5 mol % iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times.
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