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Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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Related Experiment Video

Updated: Feb 14, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
08:47

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Epileptic Encephalopathies.

Shaun A Hussain

    Continuum (Minneapolis, Minn.)
    |February 13, 2018
    PubMed
    Summary

    Epileptic encephalopathies present significant diagnostic and treatment challenges, often leading to poor outcomes. While genetic sequencing aids in identifying causes, targeted treatments remain limited, though some patients achieve remission with specific therapies.

    Area of Science:

    • Neurology
    • Genetics
    • Pediatric Neurology

    Background:

    • Epileptic encephalopathies are complex neurological disorders marked by seizures and cognitive decline.
    • These conditions represent a significant challenge in clinical practice due to their heterogeneity and poor prognoses.

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