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Updated: Feb 14, 2026

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
Published on: July 3, 2018
Synthesis of a Glibenclamide Cocrystal: Full Spectroscopic and Thermal Characterization
Silvério Ferreira Silva Filho1, Andreia Cardoso Pereira1, Jorge M G Sarraguça1
1Centro de Ciências Sociais, Saúde e Tecnologia (CCSST), Universidade Federal do Maranhão (UFMA), 65.900-410 Imperatriz, Maranhão, Brazil.
Abstract:
A cocrystal of glibenclamide, an antidiabetic drug classified as type II compound according to the Biopharmaceutics Classification System, has been synthesized using tromethamine as coformer in 1:1 molar ratio, by slow solvent evaporation cocrystalization. The cocrystal obtained was characterized by X-ray powder diffraction, differential scanning calorimetry, Raman, mid infrared, and near-infrared spectroscopy. The results consistently show the formation of a cocrystal between active pharmaceutical ingredients and conformer with the synthons corresponding to hydrogen bonding between hydrogen in amines of tromethamine and carbonyl and sulfonyl groups in glibenclamide.
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