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Author Spotlight: Understanding Mechanical Forces Involved in Shaping the Zebrafish Heart
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How mechanical forces shape the developing eye.

Hadi S Hosseini1, Larry A Taber2

  • 1Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA; Department of Physics, Washington University, St Louis, MO 63130, USA.

Progress in Biophysics and Molecular Biology
|February 13, 2018
PubMed
Summary
This summary is machine-generated.

Early vertebrate eye development involves optic vesicles forming the retina and lens. Physical mechanisms like differential growth and cell contraction drive this morphogenesis, with surrounding tissues guiding shape.

Keywords:
BiomechanicsComputational modelLensMorphogenesisOptic cupOptic vesicle

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Area of Science:

  • Developmental Biology
  • Biophysics
  • Computational Biology

Background:

  • Vertebrate eye development originates from optic vesicles and surface ectoderm.
  • These structures invaginate to form the optic cup (retina) and lens pit (lens).

Purpose of the Study:

  • To review hypotheses on physical mechanisms of early eye morphogenesis.
  • To present novel 3D computer models of eye development.

Main Methods:

  • Review of experimental data on eye development.
  • Development of three-dimensional finite-element computer models.

Main Results:

  • Physical forces driving morphogenesis include differential growth, actomyosin contraction, and apoptosis.
  • Tissue constraints and extracellular matrix mediate the resulting morphology.

Conclusions:

  • Early eye morphogenesis is driven by a combination of cellular processes and physical constraints.
  • Further research is needed to elucidate the regulatory mechanisms controlling eye shape precision.