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Pleiotropy, the physiologic basis for biologic fields.

John S Torday1

  • 1Department of Pediatrics, Harbor-UCLA Medical Center Torrance, CA 90502-2006, United States.

Progress in Biophysics and Molecular Biology
|February 13, 2018
PubMed
Summary
This summary is machine-generated.

Pleiotropic genes, systematically repurposed during evolution, maintain organism stability under stress. Homologies between quantum mechanics and physiology suggest shared self-organizing principles from the Universe's origin.

Keywords:
Big bangBiologic fieldExaptationFirst principles of physiologyPleiotropyQuantum mechanics

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Area of Science:

  • Evolutionary Biology
  • Quantum Biology
  • Physiology

Background:

  • Biologic organisms exhibit field-like properties.
  • Pleiotropy, the phenomenon of a single gene affecting multiple traits, is hypothesized to arise from gene repurposing (exaptations) during evolution.
  • The First Principles of Physiology (FPP) offer a framework for understanding gene selection and function.

Purpose of the Study:

  • To explore the mechanistic basis of pleiotropy within an evolutionary context.
  • To investigate the relationship between gene function, stress response, and physiological principles.
  • To identify potential homologies between quantum mechanics and biological systems.

Main Methods:

  • Conceptual analysis integrating evolutionary theory and physiology.
  • Hypothetical modeling of gene repurposing and network function under stress.
  • Comparative analysis of quantum mechanics principles and the First Principles of Physiology.

Main Results:

  • Pleiotropic genes function as a cohesive network to maintain allostasis under stress.
  • Strong homologies are identified between Quantum Mechanics and the FPP.
  • A shared self-organizing principle may underlie both quantum states (electron) and cellular behavior, potentially originating from the Big Bang.

Conclusions:

  • The study proposes a unified framework for understanding the origins and evolution of life by connecting physics and biology.
  • Identifying common principles in quantum mechanics and physiology provides a cohesive explanation for biological phenomena like pleiotropy.
  • The concept of self-organization, potentially stemming from the Universe's origin, unifies physical and biological systems.