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Updated: Feb 14, 2026

Profiling Maternal Behavior Responses During Whole-Brain Imaging
Published on: January 24, 2025
Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader-Willi syndrome
Rajeev Krishnadas1, Sally-Ann Cooper1, Alice Nicol2
1Institute of Health and Wellbeing,University of Glasgow,Glasgow,UK.
Abstract:
Prader-Willi syndrome (PWS) is a rare condition because of the deletion of paternal chromosomal material (del PWS), or a maternal uniparental disomy (mUPD PWS), at 15q11-13. Affective psychosis is more prevalent in mUPD PWS. We investigated the relationship between the two PWS genetic variants and brain-stem serotonin transporter (5-HTT) availability in adult humans. Mean brain-stem 5-HTT availability determined by [123I]-beta-CIT single photon emission tomography was lower in eight adults with mUPD PWS compared with nine adults with del PWS (mean difference -0.93, t = -2.85, P = 0.014). Our findings confirm an association between PWS genotype and brain-stem 5-HTT availability, implicating a maternally expressed/paternally imprinted gene, that is likely to account for the difference in psychiatric phenotypes between the PWS variants. Declaration of interest None.
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