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1Laboratoire de Microbiologie, EA4065 Ecosystème intestinal, probiotiques, antibiotiques, Faculté de Pharmacie de Paris, 4 Avenue de l'observatoire, 75006 Paris, Université Paris Descartes, DHU Risques et Grossesse.
Summary
Antibiotics impact the gut microbiota, increasing risks for infant pathologies and antibiotic resistance. Recent findings support more judicious antibiotic use in neonatology.
Area of Science:
- Microbiology
- Neonatal Medicine
- Pharmacology
Context:
- Antibiotics exert direct or indirect effects on the intestinal microbiota.
- Alterations in microbiota equilibrium are linked to increased pathology risk and bacterial resistance.
- Recent scientific advancements necessitate a re-evaluation of antibiotic practices.
Purpose:
- To highlight the impact of antibiotics on neonatal gut microbiota.
- To underscore the risks associated with microbiota dysbiosis.
- To advocate for a more rational approach to antibiotic use in neonatology.
Summary:
- Antibiotic administration significantly influences the intestinal microbiota in neonates.
- Disruptions to microbial balance can lead to adverse health outcomes, including disease susceptibility and the development of antibiotic-resistant bacteria.
- Emerging evidence supports the need for updated guidelines on antibiotic stewardship in neonatal care.
Impact:
- Promotes a more judicious and evidence-based use of antibiotics in neonatal intensive care.
- Aims to mitigate the long-term consequences of antibiotic exposure on infant health.
- Contributes to strategies for combating the growing threat of antimicrobial resistance.