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Regulation of FOXO Factors in Mammalian Cells

Abigail K Brown1, Ashley E Webb1

  • 1Brown University, Providence, RI, United States.

Current Topics in Developmental Biology
|February 14, 2018
PubMed

Insights

Forkhead box O (FOXO) transcription factors maintain cellular balance by responding to various signals. These factors integrate modifications to control gene expression, crucial for health and aging.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Genetics

Background:

  • Forkhead box O (FOXO) transcription factors are key regulators of cellular homeostasis.
  • They respond to diverse stimuli like growth factors, oxidative stress, and nutrient deprivation.

Purpose of the Study:

  • To elucidate the regulatory mechanisms of FOXO transcription factors.
  • To understand how FOXOs integrate posttranslational modifications to control cellular responses.

Main Methods:

  • Analysis of FOXO signaling pathways.
  • Investigation of posttranslational modifications (phosphorylation, acetylation, ubiquitination, methylation).
  • Gene expression profiling to assess FOXO-regulated programs.

Main Results:

  • FOXO activity is modulated by multiple posttranslational modifications.
  • These modifications impact FOXO localization, DNA binding, and cofactor interactions.
  • FOXO integrates these signals to orchestrate cell type-specific gene expression.

Conclusions:

  • FOXO transcription factors are critical for maintaining metabolic homeostasis and redox balance.
  • Their integrated regulatory network is essential for cellular stress response, development, and healthy aging.
Keywords:
AKTAMPKDAF-16FOXOIKKInsulin/IGF signalingJNKMAPK

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