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FOXO3 and Exceptional Longevity: Insights From Hydra to Humans
Philip M C Davy1, Richard C Allsopp1, Timothy A Donlon2
1Institute for Biogenesis Research, University of Hawaii, Honolulu, HI, United States.
Current Topics in Developmental Biology
|February 14, 2018
Summary
The FoxO3 gene is crucial for aging and longevity, influencing lifespan across species. Understanding its role offers insights into human aging processes.
Area of Science:
- Genetics and Molecular Biology
- Aging Research
- Evolutionary Biology
Background:
- Aging is a complex process influenced by multiple factors.
- Few evolutionarily conserved genes significantly impact aging and age-related phenotypes.
- The insulin/insulin-like growth factor-signaling pathway is implicated in aging.
Purpose of the Study:
- To review key findings on the FoxO3 gene and its homologs related to lifespan.
- To explore the role of FoxO3 in modulating aging and longevity.
- To provide insights into the molecular, cellular, and physiological processes of human aging.
Main Methods:
- Literature review of studies on FoxO3 gene and homologs.
- Analysis of data linking FoxO3 to lifespan in various species.
- Synthesis of findings on molecular and cellular mechanisms.
Main Results:
- FoxO3 is a key gene in the insulin/IGF-1 signaling pathway.
- FoxO3 and its homologs are evolutionarily conserved and impact lifespan across diverse species.
- FoxO3 plays a significant role in regulating aging and age-related phenotypes.
Conclusions:
- FoxO3 is a critical determinant of longevity.
- Studying FoxO3 provides valuable insights into the fundamental mechanisms of aging.
- Targeting FoxO3 pathways may offer strategies for promoting healthy aging in humans.
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