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Future directions in tardive dyskinesia research.
1University of California, San Diego, United States; California Department of State Hospitals (DSH), Psychopharmacology Resource Network, United States.
Journal of the Neurological Sciences
|February 14, 2018
Summary
Research into tardive dyskinesia (TD) is advancing with new VMAT2 inhibitors. Further research is needed to clarify TD definitions, pathophysiology, and epidemiology for better patient care and public health strategies.
Area of Science:
- Neuroscience
- Psychiatry
- Pharmacology
Background:
- Tardive dyskinesia (TD) research is experiencing a resurgence due to new VMAT2 inhibitor approvals.
- Existing knowledge gaps in TD pathophysiology, prognosis, and epidemiology persist.
- Ambiguous definitions of TD hinder clinical and basic science research.
Purpose of the Study:
- To address critical research gaps in tardive dyskinesia.
- To refine nomenclature and clinical criteria for TD and related tardive syndromes.
- To facilitate advanced surveillance, genetic, and epidemiological studies.
Main Methods:
- Review of current literature on TD and VMAT2 inhibitors.
- Analysis of existing challenges in TD research and clinical definitions.
- Proposal of future research directions and clinical integration strategies.
Main Results:
- New VMAT2 inhibitors offer therapeutic potential but do not resolve fundamental knowledge deficits in TD.
- Conflicting TD definitions impede research progress and clinical education.
- The widespread use of antipsychotics ensures TD remains a significant public health concern.
Conclusions:
- Clarifying TD nomenclature and diagnostic criteria is essential for advancing research.
- Future research should focus on epidemiology, genetics, and pathophysiology.
- Integrating expert knowledge into routine care can improve management of this neuropsychiatric condition.
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