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Related Experiment Video

Updated: Feb 14, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Takayasu Arteritis Coexisting with Sclerosing Osteomyelitis.

Tsuyoshi Shirai¹, Riiza Hanaoka¹, Yusuke Goto¹

¹Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)

|February 14, 2018

Summary

A rare case shows Takayasu arteritis (TAK) can complicate with diffuse sclerosing osteomyelitis. Early detection using bone scintigraphy and immunosuppressive treatment proved effective for both conditions.

Keywords:

Takayasu arteritis chronic recurrent multifocal osteomyelitis osteomyelitis synovitis-acne-pustulosis-hyperostosis-osteitis syndrome

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Area of Science:

Vascular Medicine
Rheumatology
Infectious Diseases

Background:

Takayasu arteritis (TAK) is a rare, chronic inflammatory disease affecting large arteries, primarily the aorta and its branches.
Osteomyelitis, a bone infection, can be a serious complication, though its association with TAK is infrequently reported.
This case highlights the importance of considering osteomyelitis in patients with TAK, particularly when bone pain or swelling is present.

Observation:

A 27-year-old woman initially presented with sclerosing osteomyelitis of the mandible.
Arteritis in the carotid arteries was not initially evident.
Eight months later, she developed neck pain, and imaging confirmed Takayasu arteritis in the left carotid artery.

Findings:

The patient was diagnosed with Takayasu arteritis complicated by diffuse sclerosing osteomyelitis.
Initiation of immunosuppressive therapy led to effective management of both the arteritis and the osteomyelitis.
Bone scintigraphy was identified as a valuable diagnostic tool for detecting osteomyelitis in this context.

Implications:

Osteomyelitis represents a significant, albeit rare, complication of Takayasu arteritis.
Integrated diagnostic approaches, including bone scintigraphy, are crucial for timely identification of osteomyelitis in TAK patients.
Effective immunosuppressive treatment can successfully manage both the vascular and infectious complications of TAK.