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Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating

Courtney S Malo1,2, Matthew A Huggins1,2, Emma N Goddery1,2

  • 1Department of Immunology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Nature Communications
|February 14, 2018
PubMed

The contribution of antigen-presenting cell (APC) types in generating CD8+ T cell responses in the central nervous system (CNS) is not fully defined, limiting the development of vaccines and understanding of immune-mediated neuropathology. Here, we generate a transgenic mouse that enables cell-specific deletion of the H-2Kb MHC class I molecule. By deleting H-2Kb on dendritic cells and macrophages, we compare the effect of each APC in three distinct models of neuroinflammation: picornavirus infection, experimental cerebral malaria, and a syngeneic glioma. Dendritic cells and macrophages both activate CD8+ T cell responses in response to these CNS immunological challenges. However, the extent to which each of these APCs contributes to CD8+ T cell priming varies. These findings reveal distinct functions for dendritic cells and macrophages in generating CD8+ T cell responses to neurological disease.

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