Acute Hepatocellular Jaundice After Dofetilide Initiation: A Case Report

Area of Science:

• Pharmacology
• Hepatology
• Clinical Case Reports

Background:

• Hepatotoxicity of dofetilide is not well-documented.
• Atrial fibrillation is a common cardiac arrhythmia.
• Drug-induced liver injury (DILI) is a significant clinical concern.

Purpose of the Study:

• To report a case of acute hepatocellular jaundice associated with dofetilide.
• To investigate the potential for dofetilide-induced liver injury.
• To contribute to the understanding of rare adverse drug reactions.

Main Methods:

• Case report of a 33-year-old male patient.
• Review of clinical presentation and laboratory findings.
• Exclusion of alternative causes for hepatocellular damage.

Main Results:

• The patient developed acute hepatocellular jaundice during dofetilide treatment.
• Viral and ischemic etiologies for liver damage were ruled out.
• The clinical presentation was consistent with idiosyncratic drug-induced liver injury.

Conclusions:

• Dofetilide may cause idiosyncratic liver injury.
• This case represents a rare but plausible adverse effect of dofetilide.
• Further investigation into dofetilide hepatotoxicity may be warranted.