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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Antithrombotic therapy in TAVI.

Manolis Vavuranakis1, Konstantinos Kalogeras1, Angelos Michail Kolokathis1

  • 1The First Department of Cardiology, Hippokration Hospital, Medical School, National & Kapodistrian University of Athens, Ilioupoli, Greece.

Journal of Geriatric Cardiology : JGC
|February 14, 2018
PubMed
Summary
This summary is machine-generated.

Optimal antithrombotic therapy after transcatheter aortic valve implantation (TAVI) is debated. Aspirin plus clopidogrel is common, but optimal duration and anticoagulation strategies require further research to balance bleeding and thromboembolic risks.

Keywords:
AntiplateletsAntithromboticBleedingStrokeTranscatheter aortic valve implantation

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Thrombosis

Background:

  • Transcatheter aortic valve implantation (TAVI) is associated with significant risks of thromboembolism and bleeding.
  • Optimal antithrombotic strategies post-TAVI remain a critical clinical question.

Purpose of the Study:

  • To review existing literature on antithrombotic strategies following TAVI.
  • To evaluate the impact of different antithrombotic regimens on clinical outcomes.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs), registries, and non-randomized trials.
  • Analysis of studies investigating antiplatelet and anticoagulant therapies post-TAVI.

Main Results:

  • Four RCTs showed aspirin lifelong plus clopidogrel for 3-6 months.
  • Seventeen registries reported variable clopidogrel durations (3-12 months).
  • Limited data exist for anticoagulation in patients with atrial fibrillation post-TAVI.

Conclusions:

  • Careful evaluation of antithrombotic therapy is crucial due to patient frailty.
  • Balancing ischemic and bleeding complications is the primary challenge.
  • Further research is needed to establish optimal antithrombotic protocols after TAVI.