Related Experiment Video

Updated: Feb 14, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

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Mitogen-activated protein kinase signaling pathway in oral cancer

Qian Peng1, Zhiyuan Deng1, Hao Pan1

  • 1Xiangya Stomatological Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Oncology Letters
|February 14, 2018
PubMed

Insights

The mitogen-activated protein kinase (MAPK) signaling pathway drives oral cancer progression. Understanding its sub-pathways and targeting them offers potential for improved oral cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The mitogen-activated protein kinase (MAPK) signaling pathway regulates critical cellular processes.
  • Dysregulation of the MAPK pathway is implicated in various cancers, including oral cancer.

Purpose of the Study:

  • To review the role of the MAPK signaling pathway in oral cancer progression and invasion.
  • To explore therapeutic strategies targeting the MAPK pathway for oral cancer treatment.

Main Methods:

  • Literature review of individual MAPK sub-pathways and their mechanisms.
  • Analysis of pathway interactions and clinical practice modes.

Main Results:

  • The MAPK pathway significantly influences oral cancer cell proliferation, differentiation, apoptosis, angiogenesis, invasion, and metastasis.
  • Specific sub-pathways within the MAPK cascade are key drivers of oral cancer progression.

Conclusions:

  • Targeting the MAPK signaling pathway holds promise for novel oral cancer therapies.
  • Overcoming challenges in MAPK pathway regulation requires further research into its components and interactions.
Keywords:
inhibitorkinasemitogen-activated protein kinase signaling pathwayoral canceroral squamous cell carcinomatherapeutic targetstreatment

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