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Updated: Feb 14, 2026

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Downregulated cytoplasmic polyadenylation element-binding protein-4 is associated with the carcinogenesis of head and

Manli Zeng1, Fen Li1,2, Lei Wang1

  • 1Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Oncology Letters
|February 14, 2018
PubMed

Insights

Cytoplasmic polyadenylation element-binding protein-4 (CPEB4) is downregulated in head and neck squamous cell carcinoma (HNSCC). This suggests CPEB4 may act as a tumor suppressor, offering potential for HNSCC prognosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cytoplasmic polyadenylation element-binding protein-4 (CPEB4) plays a role in cancer progression.
  • The association between CPEB4 expression and head and neck squamous cell carcinoma (HNSCC) is not well understood.

Purpose of the Study:

  • To investigate the role of CPEB4 in HNSCC.
  • To analyze CPEB4 expression levels and their correlation with clinicopathological features in HNSCC.

Main Methods:

  • Analysis of CPEB4 gene expression in six Gene Expression Omnibus (GEO) datasets.
  • Immunohistochemical staining of CPEB4 protein in an HNSCC tissue microarray (TMA).
  • Assessment of CPEB4 gene methylation in HNSCC samples.

Main Results:

  • *CPEB4* gene expression was significantly downregulated in HNSCC compared to normal tissues.
  • CPEB4 protein levels were decreased in HNSCC tumors and negatively correlated with histological grade.
  • Increased methylation of the *CPEB4* gene was observed in HNSCC, suggesting a mechanism for its downregulation.

Conclusions:

  • CPEB4 may function as a tumor suppressor gene in HNSCC.
  • Downregulation of CPEB4, potentially due to hypermethylation, contributes to HNSCC tumorigenesis.
  • CPEB4 holds potential as a prognostic biomarker for HNSCC.
Keywords:
Gene Expression Omnibus datasetcytoplasmic polyadenylation element-binding protein-4head and neck squamous cell carcinomahypermethylationtissue microassay

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