Related Experiment Video
Updated: Feb 14, 2026
07:42
Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
Published on: September 17, 2016
13.4K
Circadian clock and oral cancer
Minou Nirvani1, Cuong Khuu1, Tor Paaske Utheim1,2
1Department of Oral Biology, Faculty of Dentistry, University of Oslo, 0316 Oslo, Norway.
Molecular and Clinical Oncology
|February 14, 2018
Summary
Circadian clock genes influence oral cancer development. Altered expression of Period 1 (PER1) may play a role in oral squamous cell carcinoma, but further research is needed.
Area of Science:
- Chronobiology
- Molecular Oncology
- Oral Cancer Research
Background:
- Circadian clocks, regulated by clock genes, govern physiological rhythms in mammals.
- Disruptions in clock gene expression are linked to various pathologies, including cancer.
- The role of clock genes in oral epithelium homeostasis and oral carcinogenesis is not well understood.
Purpose of the Study:
- To review the current understanding of clock gene implications in oral cancer.
- To highlight the association between circadian rhythms and oral squamous cell carcinoma progression.
- To emphasize the potential role of Period 1 (PER1) in oral cancer pathogenesis.
Main Methods:
- Literature review of studies on circadian clock genes and oral cancer.
- Analysis of research linking clock gene expression to tumor characteristics.
- Examination of evidence for PER1 involvement in oral cancer development.
Main Results:
- Oral squamous cell carcinoma development exhibits circadian oscillations in tumor volume and proliferation.
- Altered expression of the circadian clock gene Period 1 (PER1) is associated with oral cancer.
- Changes in PER1 expression may influence the development, invasion, and metastasis of oral squamous cell carcinoma.
Conclusions:
- Clock genes are implicated in oral cancer pathogenesis.
- PER1's specific role in oral cancer requires further investigation.
- Understanding clock gene mechanisms is crucial for advancing oral cancer research.
More Related Videos
10:38Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
23.2K
07:44In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
Published on: July 4, 2018
8.9K
Related Concept Videos
02:45Biological Clocks and Seasonal Responses
41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
01:11Oral Cavity
3.2K
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
3.2K
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
392
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
392
01:06Oral Hypoglycemic Agents: Glinides
700
Repaglinide (Prandin) and Nateglinide (Starlix), known as glinides, are oral insulin secretagogues that stimulate insulin release from pancreatic β cells by closing the ATP-sensitive potassium channels (KATP channel). Repaglinide controls insulin release from pancreatic β cells by managing potassium efflux. It shares two binding sites with sulfonylureas and also has a unique site, indicating overlapping mechanisms of action. With a rapid onset and a 4-7 hour duration, it effectively...
700
01:16Psychosexual Stages of Personality: Oral
3.3K
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring...
Weaning, typically occurring...
3.3K