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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
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Mantle Cell Lymphoma in the Thyroid: A Rare Presentation.
Uzma Mohammad Siddiqui1, Sarika N Rao2, Pallavi Kanwar Galera3
1Division of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA.
Case Reports in Pathology
|February 14, 2018
Summary
Primary thyroid mantle cell lymphoma (MCL) is rare. This case highlights a low-grade MCL with a favorable prognosis, suggesting observation may be suitable for select patients.
Area of Science:
- Oncology
- Hematology
- Endocrinology
Background:
- Extranodal Non-Hodgkin Lymphoma rarely involves the thyroid (2%).
- Mantle Cell Lymphoma (MCL) incidence in thyroid lymphomas is <1%.
- Limited data necessitates understanding thyroidal MCL disease course.
Observation:
- A 65-year-old female with multinodular goiter presented with dysphagia.
- Initial fine needle aspirations suggested Hashimoto's thyroiditis; flow cytometry was negative.
- Total thyroidectomy was performed due to symptom progression.
Findings:
- Pathology confirmed MCL with a mantle zone growth pattern in the thyroid.
- Flow cytometry revealed monoclonal B cells (9%); Ki-67 index was 10%.
- Diagnosis: Stage IIE MCL, managed conservatively due to absence of B symptoms.
Implications:
- Low-grade MCL with mantle zone pattern and Ki-67 <10% indicates a favorable prognosis.
- Observation may be an option for select MCL patients, contrasting with standard chemotherapy.
- Primary thyroidal MCL is rare; evolving staging and treatment modalities are crucial.
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