Study-based registers of randomized controlled trials: Starting a systematic review with data extraction or...

Area of Science:

• Biomedical Research
• Data Management
• Scientific Publishing

Background:

• Study-based registers are essential for scientific reviewing, particularly for randomized controlled trials (RCTs).
• The methodology for developing these critical databases has historically been undocumented.
• This paper addresses the need for documented methodologies in register development.

Purpose of the Study:

• To document and discuss the methodological aspects of developing and utilizing study-based registers.
• To provide a framework applicable to various study types beyond clinical trials.
• To highlight the importance of registers for systematic reviews.

Main Methods:

• Describing the necessity and rationale for study-based register development.
• Outlining the key steps involved in the creation, utilization, and maintenance of registers.
• Discussing the challenges and benefits for organizations supporting systematic reviews.

Main Results:

• A documented methodology for the development and use of study-based registers is presented.
• The applicability of this methodology extends to diverse research areas, including human, animal, cellular, and molecular studies.
• The process highlights gains for organizations involved in systematic reviews.

Conclusions:

• Study-based registers are fundamental for the efficient production of systematic reviews.
• The development of robust register infrastructures is an inevitable and beneficial progression in scientific research.
• These registers facilitate the rapid and accurate delivery of evidence to decision-makers.