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Stimuli-responsive chitosan-based nanocarriers for cancer therapy
Marziyeh Fathi1, Parham Sahandi Zangabad1, Sima Majidi2
1Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Bioimpacts : BI
|February 14, 2018
Summary
Chitosan (CS)-based stimuli-responsive nanocarriers offer advanced drug delivery systems (DDSs) for targeted cancer therapy. These smart nanosystems enable on-demand drug release, improving treatment efficacy and diagnosis.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Stimuli-responsive nanocarriers provide targeted drug delivery and on-demand release capabilities.
- Chitosan (CS)-based drug delivery systems (DDSs) exhibit excellent biocompatibility and biodegradability.
Purpose of the Study:
- To review recent advancements in stimuli-responsive nanocarriers, focusing on CS-based nanosystems.
- To discuss the applications of these CS-based nanosystems in cancer therapy and diagnosis.
Main Methods:
- Literature survey of stimuli-responsive nanocarriers.
- Analysis of recent developments in CS-based nanosystems.
- Review of applications in cancer treatment and diagnostics.
Main Results:
- CS-based DDSs are ideal smart, multifunctional systems due to biocompatibility, biodegradability, and ease of functionalization.
- These nanocarriers respond to endogenous (pH, enzymes) or exogenous (light, temperature) stimuli for controlled release.
- Dual-responsive nanocarriers offer enhanced efficiency for drug delivery.
Conclusions:
- CS-based stimuli-responsive multifunctional nanosystems show significant potential for targeted anticancer drug delivery.
- These systems enable precise, on-demand release of therapeutic agents, improving cancer treatment outcomes.
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