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Quantitative Autonomic Testing
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Autonomic function testing in spinocerebellar ataxia type 2.

Elisabetta Indelicato1, Alessandra Fanciulli2, Jean Pierre Ndayisaba1

  • 1Department of Neurology, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|February 14, 2018
PubMed
Summary

Autonomic failure is not a typical feature of spinocerebellar ataxia type 2 (SCA2). However, bladder and skin sweating abnormalities may occur in SCA2 patients, suggesting other autonomic domains can be affected.

Keywords:
Cardiovascular autonomic function testingOlivo-ponto-cerebellar atrophyOrthostatic hypotensionSkin sympathetic reflexSpinocerebellar ataxia type 2

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Area of Science:

  • Neurology
  • Genetics
  • Autonomic Neuroscience

Background:

  • Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder affecting cerebellar and brainstem function.
  • Autonomic dysfunction can manifest in various neurological conditions, but its role in SCA2 requires further investigation.

Purpose of the Study:

  • To determine if autonomic failure is part of the clinical spectrum of spinocerebellar ataxia type 2 (SCA2).

Main Methods:

  • Cardiovascular autonomic function was assessed in 8 SCA2 patients and 16 healthy controls.
  • Autonomic domains including bladder function and sudomotor reflex were evaluated using questionnaires and specific tests.

Main Results:

  • SCA2 patients exhibited normal cardiovascular autonomic function, except for reduced baroreflex sensitivity.
  • Bladder disturbances were reported by 7/8 SCA2 patients, and 3/6 patients lacked skin sympathetic reflex.

Conclusions:

  • Clinically apparent cardiovascular autonomic failure was not observed in SCA2.
  • Bladder and sudomotor functions may be affected in spinocerebellar ataxia type 2, indicating potential involvement of other autonomic domains.