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Related Experiment Video

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Demonstration of Cutaneous Allodynia in Association with Chronic Pelvic Pain
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Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain.

E Ikeda1, T Li1, H Kobinata1

  • 1Department of Anesthesiology, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Japan.

European Journal of Pain (London, England)
|February 14, 2018
PubMed
Summary
This summary is machine-generated.

Chronic pain is linked to reduced grey matter volume in brain regions like the insular cortex and altered reward system connectivity. These changes correlate with pain catastrophizing and depression, suggesting a brain signature for pain chronification.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Research

Background:

  • Chronic pain involves anatomical and functional brain changes.
  • Regional grey matter volume alterations may correlate with brain network activity.

Purpose of the Study:

  • Identify brain regions with grey matter volume changes in chronic pain patients.
  • Analyze functional connectivity alterations in these regions.
  • Explore the relationship between these changes and pain psychometrics.

Main Methods:

  • Cross-sectional observational study.
  • Recruited 23 chronic pain patients and 17 healthy controls.
  • Utilized resting-state fMRI and 3D anatomical imaging on a 3 Tesla MRI scanner.

Main Results:

  • Chronic pain patients showed decreased grey matter volume in the right anterior insular cortex and left middle cingulate cortex.
  • Reduced connectivity was observed between the right anterior insular cortex and left nucleus accumbens.
  • This decreased connectivity negatively correlated with Pain Catastrophizing Scale and Beck's Depression Inventory scores.

Conclusions:

  • Decreased grey matter volumes in affective pain processing regions may be a common feature of chronic pain.
  • Dysfunctional connectivity within the insular cortex-nucleus accumbens network may indicate affective and motivational deficits.
  • These anatomical and functional brain alterations could represent a signature for pain chronification.