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Updated: Feb 14, 2026

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
05:31

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients

Published on: September 20, 2020

6.2K

Chemoembolization related to good survival for selected patients with hepatocellular carcinoma invading segmental

Jin Hyoung Kim1, Ju Hyun Shim2, Hyun-Ki Yoon1

  • 1Department of Radiology and Research Institute of Radiology, Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Liver International : Official Journal of the International Association for the Study of the Liver
|February 14, 2018
PubMed

Insights

Transarterial chemoembolization (TACE) is effective for selected hepatocellular carcinoma (HCC) patients with segmental portal vein tumor thrombosis (PVTT). Four risk factors predict poor survival, suggesting TACE may not be suitable for patients with multiple risk factors.

Area of Science:

  • Hepatobiliary Oncology
  • Interventional Radiology
  • Prognostic Factor Analysis

Background:

  • Hepatocellular carcinoma (HCC) with segmental portal vein tumor thrombosis (PVTT) presents a treatment challenge.
  • Transarterial chemoembolization (TACE) is a common treatment modality for HCC.

Purpose of the Study:

  • To evaluate survival outcomes after TACE in patients with HCC and segmental PVTT.
  • To identify independent prognostic factors influencing survival in this patient cohort.

Main Methods:

  • Retrospective analysis of 331 patients with HCC and segmental PVTT treated with TACE between 1997 and 2015.
  • Multivariable Cox regression analysis to determine prognostic factors for survival.

Main Results:

  • Median survival was 10.7 months; 1-, 3-, and 5-year survival rates were 44.9%, 16%, and 12%.
  • Objective tumor response to TACE was observed in 53.8% of patients.
  • Independent prognostic factors for survival included up-to-11 criteria, extrahepatic metastasis, Child-Pugh class, and tumor response to TACE.

Conclusions:

  • TACE is well-tolerated and effective in selected HCC patients with segmental PVTT.
  • Major tumor burden, extrahepatic spread, Child-Pugh class B, and lack of tumor regression are associated with decreased survival.
  • TACE may not be recommended for patients with 2-4 identified risk factors due to poor survival outcomes.
Abstract

Keywords:
hepatocellular carcinomaportal vein tumour thrombosissurvival analysistransarterial chemoembolization

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