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Coronary Flow Reserve in Non-Infarcted Myocardium Predicts Long-Term Clinical Outcomes in Patients Undergoing

Rongchao Cheng1, Xiaoming Zhu2, Yunling Li1

  • 1Department of Cardiology, the Forth Affiliated Hospital of Harbin Medical University, Harbin, China.

Yonsei Medical Journal
|February 14, 2018
PubMed

Insights

Coronary flow reserve (CFR) in non-infarcted heart muscle predicts future major adverse cardiac events (MACEs) after acute myocardial infarction (AMI) and percutaneous coronary intervention (PCI). Lower CFR indicates a higher risk of MACEs within 12 months.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Myocardial Perfusion Assessment

Background:

  • Coronary flow reserve (CFR) is a key indicator of myocardial perfusion.
  • Assessing CFR in non-infarcted areas may offer prognostic value in acute myocardial infarction (AMI) patients.

Purpose of the Study:

  • To evaluate the association between non-infarcted myocardial CFR and the incidence of major adverse cardiac events (MACEs).
  • To determine if CFR predicts 12-month MACEs in patients with AMI undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • 100 patients with AMI post-PCI were categorized into MACE and non-MACE groups based on 12-month outcomes.
  • Left ventricular function and CFR were assessed using echocardiography and myocardial contrast echocardiography one week post-PCI.
  • Peak cardiac troponin I levels were measured.

Main Results:

  • Patients experiencing MACEs had significantly lower CFR compared to the non-MACE group (2.41 vs. 2.77, p<0.001).
  • Multivariable analysis identified non-infarcted myocardial CFR as an independent predictor of 12-month MACEs (HR: 0.093, 95% CI: 0.020-0.426, p=0.002).

Conclusions:

  • CFR in the non-infarcted myocardium serves as a valuable marker for predicting 12-month MACEs.
  • This finding is significant for patients with AMI undergoing primary PCI.
Abstract

Keywords:
Myocardial infarctioncoronary flow reservemicrovascular dysfunctionmyocardial contrast echocardiography

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