Related Experiment Video

Updated: Feb 14, 2026

MEDUSA for Identifying Death Regulatory Genes in Chemo-genetic Profiling Data
07:17

MEDUSA for Identifying Death Regulatory Genes in Chemo-genetic Profiling Data

Published on: February 7, 2025

938

Infant deaths from congenital anomalies: novel use of Child Death Overview Panel data

Catriona Firth1,2, Emily Petherick3,4, Sam J Oddie1,5

  • 1Bradford Royal Infirmary, Neonatal Unit, Bradford, UK.

Archives of Disease in Childhood
|February 14, 2018
PubMed

Insights

Child Death Overview Panel (CDOP) data showed moderate to perfect agreement with birth cohort data, except for ethnicity. Pakistani infants had the highest infant mortality rates (IMRs), particularly from congenital anomalies (CA), linked to consanguinity.

Area of Science:

  • Perinatal epidemiology
  • Public health surveillance
  • Biostatistics

Background:

  • Accurate infant mortality data is crucial for public health interventions.
  • Child Death Overview Panels (CDOP) are a key source of this data, but their validity requires assessment.
  • Understanding causes of infant death, including congenital anomalies (CA), is vital for targeted prevention strategies.

Purpose of the Study:

  • To validate Child Death Overview Panel (CDOP) data against a local birth cohort (Born in Bradford, BiB) and a separate coding system (CODAC).
  • To calculate ethnic-specific infant mortality rates (IMRs) using CDOP data.
  • To compare characteristics of infants who died from congenital anomalies (CA) versus other causes.

Main Methods:

  • Retrospective cohort study of infant deaths in Bradford Metropolitan District (2008-2013).
  • Comparison of CDOP data with Born in Bradford (BiB) cohort data for characteristics and cause of death classification.
  • Analysis of infant mortality rates (IMRs) stratified by ethnicity and cause of death (CA vs. non-CA).

Main Results:

  • Moderate to perfect agreement was found between CDOP and BiB data for most characteristics, with weaker agreement for ethnicity (kappa=0.58).
  • Congenital anomalies (CA) were classified similarly by CDOP and CODAC (27/56 deaths).
  • Infant mortality rates (IMRs) were highest in Pakistani infants (9.8/1000 live births overall, 5.5/1000 for CA) compared to white British (4.3/1000 overall, 1.3/1000 for CA).
  • Infants dying from CA were more likely to be born at term (OR 3.18) and to consanguineous parents (OR 3.28) than those dying from non-CA causes.

Conclusions:

  • CDOP data demonstrates reasonable validity for assessing infant mortality, though ethnicity data requires careful interpretation.
  • Excess infant mortality among Pakistani infants is partly attributable to a higher incidence of deaths from congenital anomalies (CA).
  • Consanguinity appears to be a significant risk factor associated with congenital anomaly deaths in this population.
Abstract

Keywords:
congenital anomalyethnicityinfant mortality

More Related Videos

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.4K
Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response06:06

Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response

Published on: November 10, 2023

2.0K

Related Concept Videos

Overview of Cell Death01:30

Overview of Cell Death

Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
10.3K
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and...
4.6K
Wood Panel Products01:18

Wood Panel Products

Wood panel products are essential materials used in construction for applications such as flooring, siding, and roofing, typically available in standard dimensions of 4 feet by 8 feet, with thicknesses varying from one-quarter of an inch to one and one-eighth inches. Among the most common types of wood panels is plywood, which is produced by gluing multiple layers of thin wood veneers under pressure. The grain of the outer veneers runs lengthwise, while the grains of the interior layers run...
418
Overview of Microsoft Excel as a Data Analysis Tool01:13

Overview of Microsoft Excel as a Data Analysis Tool

Microsoft Excel is a cornerstone tool for data analysis and statistical operations, offering a wide array of functionalities to manage, analyze, and visualize data efficiently. Recognized for its versatility, Excel facilitates the performance of basic to complex statistical operations, serving as an indispensable asset for analysts, researchers, and students alike. Excel's significance in data analysis emanates from its spreadsheet environment, where data can be organized in rows and...
1.7K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
34.0K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
335