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An acute transfusion reaction.
Clare Webb1, Alan Norris2, Katie Hands2
1NHS Tayside, Dundee, UK.
Clinical Medicine (London, England)
|February 14, 2018
Summary
A severe allergic transfusion reaction occurred in a patient with IgA deficiency due to anti-IgA antibodies. This highlights transfusion risks versus benefits, especially in patients with immunoglobulin A deficiency.
Area of Science:
- Immunology
- Transfusion Medicine
- Allergy
Background:
- Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency.
- Patients with IgA deficiency can develop antibodies to IgA, including anti-IgA antibodies.
- Blood product transfusions carry inherent risks, including allergic reactions.
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