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Vandetanib inhibits cisplatin‑resistant neuroblastoma tumor growth and invasion

Changchun Li1, Chao Yang1, Guanghui Wei2

  • 1Department of Pediatric Surgical Oncology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, P.R. China.

Oncology Reports
|February 14, 2018
PubMed

Insights

Vandetanib shows promise for treating cisplatin-resistant neuroblastoma (NB). This drug inhibits cancer cell growth and invasion, offering a potentially less toxic alternative to high-dose cisplatin for NB therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Cisplatin resistance is a primary obstacle in neuroblastoma (NB) treatment.
  • Vandetanib is an established therapeutic agent for various cancers.

Purpose of the Study:

  • To evaluate the efficacy of Vandetanib in overcoming cisplatin resistance in neuroblastoma.
  • To investigate the role of p-RET and CXCR4 in cisplatin-resistant NB.

Main Methods:

  • Immunohistochemistry (IHC) to assess p-RET and CXCR4 expression in NB tissues.
  • In vitro assays (CCK8, colony formation, invasion) on cisplatin-resistant SH-SY5Y cells.
  • In vivo studies using mouse models to evaluate tumor growth and toxicity.

Main Results:

  • Elevated p-RET and CXCR4 expression observed in cisplatin-resistant NB.
  • Vandetanib treatment significantly reduced proliferation, colony formation, and invasion of resistant NB cells.
  • Vandetanib demonstrated comparable efficacy to high-dose cisplatin in reducing tumor growth with lower liver toxicity.

Conclusions:

  • Vandetanib effectively targets cisplatin-resistant neuroblastoma cells by downregulating p-RET and CXCR4.
  • Vandetanib presents a promising therapeutic option for cisplatin-resistant NB, with a favorable toxicity profile.

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