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Risk analysis factors for local recurrence in Ewing's sarcoma: when should adjuvant radiotherapy be administered?
J I Albergo1, C L L Gaston2, M C Parry3
1Hospital Italiano de Buenos Aires, Peron 1190 (c1199abd), Buenos Aires, Argentina and Royal Orthopaedic Hospital, Bristol Road South, Birmingham B31 2AP, UK.
The Bone & Joint Journal
|February 14, 2018
Summary
Radiotherapy can reduce local recurrence in limb Ewing
Area of Science:
- Orthopedics
- Oncology
- Surgical Oncology
Background:
- Ewing's sarcoma is a rare bone cancer.
- Local recurrence is a significant factor affecting survival in Ewing's sarcoma patients.
Purpose of the Study:
- To analyze prognostic factors for local recurrence in non-metastatic Ewing's sarcoma.
- To assess the role of radiotherapy in preventing local recurrence.
Main Methods:
- Retrospective review of 388 patients with Ewing's sarcoma treated between 1980 and 2012.
- Patients received chemotherapy followed by surgery and/or radiotherapy.
- Analysis of prognostic factors based on tumor site (central vs. limb).
Main Results:
- 15% of patients developed local recurrence.
- Tumor size and chemotherapy response impacted recurrence in central tumors.
- Marginal resections and radiotherapy use affected recurrence in limb tumors.
- Radiotherapy reduced local recurrence risk in limb tumors with marginal resections (5yrLRFS: 96% vs. 81%).
Conclusions:
- Local recurrence negatively impacts overall survival in Ewing's sarcoma.
- Radiotherapy is beneficial for reducing local recurrence in limb tumors, particularly with marginal resections.
- The role of radiotherapy in central tumors and with wide resections requires further investigation.
