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Updated: Feb 14, 2026

High Throughput Sequential ELISA for Validation of Biomarkers of Acute Graft-Versus-Host Disease
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Published on: October 31, 2012

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B-cell targeting in chronic graft-versus-host disease

Robert Zeiser1, Stefanie Sarantopoulos2, Bruce R Blazar3

  • 1Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University, Freiburg, Germany.

Blood
|February 14, 2018
PubMed

Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.

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