Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermodynamics: Chemical Potential and Activity01:10

Thermodynamics: Chemical Potential and Activity

1.8K
The effective concentration of a species in a solution can be expressed precisely in terms of its activity. Activity considers the effect of electrolytes present in the vicinity of the species of interest and depends on the ionic strength of the solution. The activity of a species is expressed as the product of molar concentration and the activity coefficient of the species.
The thermodynamic equilibrium constant is more accurately defined in terms of activity rather than concentration.
1.8K
Molecules and Compounds02:38

Molecules and Compounds

69.7K
Atoms and Molecules
69.7K
Potential Energy00:52

Potential Energy

43.0K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
43.0K
Classification of Elements and Compounds02:54

Classification of Elements and Compounds

73.8K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.8K
Organic Compounds03:02

Organic Compounds

57.7K
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
57.7K
Elements and Compounds01:27

Elements and Compounds

105.5K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
105.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

Successful use of vincristine in a quarter horse gelding with immune-mediated thrombocytopenia.

Journal of equine veterinary science·2026

Related Experiment Video

Updated: Feb 14, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.8K

Compounds with Potential Activity against Mycobacterium tuberculosis.

C Sao Emani1,2, M J Williams3, I J Wiid3

  • 1DST-NRF Centre of Excellence in Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, and Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa karallia@sun.ac.za brubaker@sun.ac.za Carlo.Carolis@crg.eu.

Antimicrobial Agents and Chemotherapy
|February 14, 2018
PubMed
Summary

New tuberculosis drugs are urgently needed due to rising resistance. This study screened compounds, finding azaguanine, sulfaguanidine, bacitracin, and fusaric acid show promise against Mycobacterium tuberculosis by affecting thiol levels and oxidative stress.

Keywords:
antimicrobial agentsoxidative stresssusceptibility testingthiols

More Related Videos

Growth of Mycobacterium tuberculosis Biofilms
09:03

Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

24.5K
Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
08:48

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

649

Related Experiment Videos

Last Updated: Feb 14, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.8K
Growth of Mycobacterium tuberculosis Biofilms
09:03

Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

24.5K
Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis
08:48

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

649

Area of Science:

  • Microbiology
  • Drug Discovery
  • Biochemistry

Background:

  • High rates of drug resistance in Mycobacterium tuberculosis (TB) necessitate novel therapeutic agents.
  • Drug repurposing offers a viable strategy for identifying new TB treatments.

Purpose of the Study:

  • To identify existing compounds with potential activity against Mycobacterium tuberculosis.
  • To investigate the efficacy of repurposed drugs in thiol-deficient mycobacterial strains.

Main Methods:

  • High-throughput screening of compounds against thiol-deficient Mycobacterium smegmatis strains.
  • Validation of promising compounds using thiol-deficient Mycobacterium tuberculosis strains.
  • Analysis of compound effects on thiol levels and oxidative stress in M. tuberculosis.

Main Results:

  • Mutants ΔegtA and ΔmshA showed increased susceptibility to azaguanine (Aza) and sulfaguanidine (Su).
  • Mutants ΔegtB and ΔegtE exhibited increased susceptibility to bacitracin (Ba).
  • Mutants ΔegtA, ΔmshA, and ΔegtB were more susceptible to fusaric acid (Fu).
  • Some tested compounds modulated thiol levels and oxidative stress in M. tuberculosis.

Conclusions:

  • Azaguanine, sulfaguanidine, bacitracin, and fusaric acid demonstrate activity against Mycobacterium tuberculosis.
  • These compounds represent potential candidates for novel TB treatment regimens.
  • Further research is warranted to explore the therapeutic potential of these agents.