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Related Experiment Videos

Glaucoma treatment with timolol.

E Kerty, I Hørven

    Acta Ophthalmologica
    |October 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Topical timolol effectively controlled various glaucoma types in patients, even those with previously uncontrolled conditions. This glaucoma medication demonstrated a stronger effect than combined epinephrine and acetazolamide, with good tolerability.

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    Area of Science:

    • Ophthalmology
    • Clinical Pharmacology

    Background:

    • Glaucoma management often requires multiple medications, including pilocarpine, epinephrine, and acetazolamide, to control intraocular pressure.
    • Some patients with glaucoma remain uncontrolled despite comprehensive medical therapy, necessitating alternative treatment strategies.
    • Topical timolol is a beta-blocker used to reduce aqueous humor production in glaucoma treatment.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of topical timolol in patients with capsular glaucoma, pigmentary glaucoma, and primary open-angle glaucoma.
    • To compare the effect of topical timolol with existing combination therapies, including epinephrine and acetazolamide.

    Main Methods:

    • A 3-6 month follow-up study involving 19 patients (32 eyes) with various types of glaucoma.

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  • Patients received topical timolol (0.5% twice daily), with or without pilocarpine.
  • Treatment outcomes were assessed based on intraocular pressure control and the need for additional medications or surgery.

    • Main Results:

    • Topical timolol, alone or in combination with pilocarpine, adequately controlled glaucoma in 8 out of 12 previously uncontrolled eyes, eliminating the need for acetazolamide.
    • In 12 eyes previously controlled on other medications, timolol provided equivalent or better control, allowing discontinuation of acetazolamide in all six patients using it.
    • All 8 untreated eyes were adequately controlled with timolol or timolol and pilocarpine.
    • Timolol 0.5% twice daily appeared more potent than combined epinephrine 1% twice daily and acetazolamide 500 mg daily.
    • Topical timolol was well-tolerated, with no reported side effects or impact on pupillary size or reactions.

    Conclusions:

    • Topical timolol is an effective and well-tolerated treatment for various glaucoma types, including those resistant to other medications.
    • Timolol may offer a superior or comparable therapeutic effect to combination therapies involving epinephrine and acetazolamide.
    • The use of topical timolol can potentially reduce or eliminate the need for systemic acetazolamide in glaucoma management.