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The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

Tomokazu Yamaguchi1, Takashi Suzuki1, Teruki Sato2

  • 1Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.

Science Signaling
|February 14, 2018
PubMed
Summary

The CCR4-NOT complex prevents heart failure by regulating mRNA deadenylation. Its disruption leads to autophagic cell death, highlighting deadenylation

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