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Updated: Feb 14, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Diastereoselective synthesis of chiral 1,3-cyclohexadienals
Aitor Urosa1, Ignacio E Tobal1, Ángela P de la Granja1
1Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Salamanca, Spain.
Abstract:
A novel approach to the production of chiral 1,3-cyclohexadienals has been developed. The organocatalysed asymmetric reaction of different β-disubstituted-α,β-unsaturated aldehydes with a chiral α,β-unsaturated aldehyde in the presence of a Jørgensen-Hayashi organocatalyst provides easy and stereocontrolled access to the cyclohexadienal backbone. This method allows for the synthesis of potential photoprotective chiral 1,3-cyclohexadienals and extra extended conjugation compounds in a simple manner.
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