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Updated: Feb 14, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
DOSE DISTRIBUTION IN A BREAST UNDERGOING MAMMOGRAPHY BASED ON A 3D DETAILED BREAST MODEL FOR CHINESE WOMEN
Wenjing Wang1,2, Rui Qiu1,2, Li Ren1,2
1Department of Engineering Physics, Tsinghua University, Beijing, China.
Abstract:
Not only the mean glandular dose (MGD) but also the glandular dose distribution is important in describing the radiation exposure to breast in mammography. For a more precise knowledge of the absorbed dose distribution in the breast, experimental measurements with thermoluminescence dosemeter and Monte Carlo simulations with Geant4 were performed in this study. The experimental measurements with homogeneous physical breast phantoms were used to validate Monte Carlo simulations of homogeneous mathematical breast models undergoing mammography. Then a 3D detailed breast model with a compressed breast thickness of 4 cm and a glandular content of 50%, which has been constructed in previous work, was used to study the absorbed dose distribution inside the breast undergoing mammography. Furthermore, the effects of the glandular tissue distribution on MGD were studied by reversing the breast model in head-toe direction to get a breast model with a different distribution of glandular tissues.
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