Related Experiment Video
Updated: Feb 14, 2026
08:34
Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.8K
FAT10 attenuates hypoxia-induced cardiomyocyte apoptosis by stabilizing caveolin-3
Qiongqiong Zhou1, Xiaogang Peng2, Xiao Liu1
1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
Journal of Molecular and Cellular Cardiology
|February 14, 2018
Summary
FAT10 protein protects the heart from ischemic injury by increasing Caveolin-3 expression, thereby reducing cardiomyocyte apoptosis. This FAT10/Caveolin-3 pathway offers a potential therapeutic target for heart conditions.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Cellular Stress Response
Background:
- FAT10, a ubiquitin-like protein, offers cardioprotection against hypoxic/ischemic injury.
- Caveolin-3 (Cav-3), a muscle protein, influences cardiomyocyte apoptosis.
- The interaction between FAT10 and Cav-3 in ischemic conditions remains largely unknown.
Purpose of the Study:
- To investigate the role of FAT10 in regulating Cav-3 expression during myocardial ischemia.
- To elucidate the mechanism by which FAT10 affects cardiomyocyte apoptosis.
- To explore the therapeutic potential of the FAT10/Cav-3 axis in ischemic heart disease.
Main Methods:
- Analysis of FAT10 and Cav-3 expression in ischemic myocardial tissues and hypoxic cardiomyocytes.
- Assessment of cardiomyocyte apoptosis in FAT10 knockout models following myocardial infarction.
- Investigation of Cav-3 degradation pathways, including the ubiquitin-proteasome system (UPS).
- Experimental validation of FAT10's effect on Cav-3 ubiquitination and stability.
Main Results:
- Both FAT10 and Cav-3 expression were elevated in ischemic conditions.
- FAT10 was found to inhibit hypoxia-induced cardiomyocyte apoptosis by upregulating Cav-3.
- FAT10 knockout exacerbated cardiac dysfunction and apoptosis post-myocardial infarction due to reduced Cav-3.
- FAT10 stabilizes Cav-3 by preventing its ubiquitination-mediated degradation via the UPS.
Conclusions:
- FAT10 protects against ischemia-induced cardiac injury by stabilizing Cav-3 expression.
- The FAT10/Cav-3 axis represents a novel mechanism in cardioprotection.
- Targeting the FAT10/Cav-3 pathway may offer a new therapeutic strategy for ischemic heart disease.
Related Concept Videos
02:42Transcription Attenuation in Prokaryotes
18.6K
Transcriptional attenuation occurs when RNA transcription is prematurely terminated due to the formation of a terminator mRNA hairpin structure. Bacteria use these hairpins to regulate the transcription process and control the synthesis of several amino acids including histidine, lysine, threonine, and phenylalanine. Transcription attenuation takes place in the non-coding regions of mRNA.
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
18.6K
01:30Apoptosis
15.3K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
15.3K
01:23Hypoxia
2.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.2K
03:18Nuclear Stability
23.4K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
To hold positively charged protons together...
23.4K
01:53RNA Stability
35.8K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
02:51mRNA Stability and Gene Expression
6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
Cis-acting Elements involved in mRNA stability
6.7K