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HIPPO Stampede in Nerve Sheath Tumors
M Laura Feltri1, Yannick Poitelon2
1Hunter James Kelly Research Institute, Departments of Biochemistry and Neurology, University at Buffalo, Buffalo, NY 14203, USA.
Abstract:
Current therapies for malignant peripheral nerve sheath tumors (MPNSTs) are ineffective. The study by Wu et al. in this issue of Cancer Cell provides evidence that the HIPPO pathway is overactive in human MPNSTs and that combined modulation of LATS1/2-YAP/TAZ and PDGFR signaling in Schwann cells reduces MPNST growth.
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