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Related Experiment Video

Updated: Feb 14, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Structural MRI correlates of cognitive function in multiple sclerosis.

Artemios Artemiadis¹, Maria Anagnostouli², Ioannis Zalonis²

¹1st Department of Neurology, Aeginition Hospital, Faculty of Medicine, National Kapodistrian University of Athens, Vas. Sofias Ave. 72-74, GR-11528 Athens, Greece; Department of Neurology, Army Share Fund Hospital (NIMTS), Monis Petraki 10-12, GR-11521 Athens, Greece.

Multiple Sclerosis and Related Disorders

|February 14, 2018

Summary

This summary is machine-generated.

Magnetic resonance imaging (MRI) markers effectively predict cognitive impairment in multiple sclerosis (MS) patients. Specific MRI measures, including third ventricle width and lesion volume, are key indicators of cognitive decline in MS.

Keywords:

BICAMS Cognitive MRI Markers Multiple sclerosis Volumetric

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Area of Science:

Neuroimaging
Neurology
Cognitive Science

Background:

Cognitive impairment (CI) is a common challenge in multiple sclerosis (MS).
Numerous magnetic resonance imaging (MRI) indices have been linked to cognitive function in MS patients.
This study investigates a comprehensive set of 2D and 3D MRI markers associated with cognitive function in MS.

Purpose of the Study:

To investigate the association between a wide array of 2D and 3D MRI markers and cognitive function in patients with MS.
To identify specific MRI indices that can predict cognitive performance in MS.

Main Methods:

A cross-sectional study involving 61 relapsing-remitting MS (RRMS) patients and 51 healthy controls.
Comprehensive neuropsychological testing and a broad range of 2D/3D MRI evaluations were performed.
Statistical analyses were conducted to assess the relationship between MRI markers and cognitive scores, adjusting for age and education.

Main Results:

Cognitive impairment (CI) was present in 44.3% of MS patients.
CI patients exhibited greater disability, fatigue, and psychological distress compared to non-CI patients and healthy controls.
Significant MRI differences in CI patients included larger third ventricle width/volume, smaller corpus callosum index, and larger lesion volume.
These MRI markers significantly predicted cognitive scores, accounting for 30.6% of the total cognitive score variance.

Conclusions:

Specific linear and volumetric MRI indices demonstrate predictive value for cognitive function in MS.
Future research should focus on longitudinal changes and the development of normative MRI data for MS populations.