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The serum concentrations of perfluoroalkyl compounds were inversely associated with growth parameters in 2-year old

Young Ah Lee1, Jin Hee Kim2, Hae Woon Jung3

  • 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

The Science of the Total Environment
|February 14, 2018
PubMed

Insights

Serum perfluoroalkyl compounds (PFCs) were inversely associated with growth in 2-year-old Korean children. Higher PFC levels correlated with reduced height and weight, suggesting potential developmental impacts from these environmental contaminants.

Area of Science:

  • Environmental Health
  • Pediatric Growth
  • Toxicology

Background:

  • Perfluoroalkyl compounds (PFCs) are persistent environmental contaminants with potential health effects.
  • Understanding the impact of prenatal and early-life exposure to PFCs on child development is crucial.

Purpose of the Study:

  • To investigate the association between serum concentrations of various PFCs and growth parameters (height and weight) in 2-year-old Korean children.
  • To explore potential correlations between breastfeeding duration and serum PFC levels.

Main Methods:

  • Cross-sectional study involving 361 Korean children aged 22-27 months.
  • Measurement of serum concentrations for seven PFCs: PFHxS, PFOS, PFOA, PFNA, PFDA, PFUnDA, and PFHpA.
  • Statistical analysis to assess relationships between PFC levels, growth parameters, and breastfeeding duration, adjusting for covariates.

Main Results:

  • Seven PFCs were detected in most serum samples, with high detection rates for PFHxS, PFOS, PFOA, and PFNA.
  • Breastfeeding duration showed a positive association with serum concentrations of all measured PFCs.
  • Serum concentrations of PFHxS, PFOS, PFOA, PFNA, and PFDA were inversely associated with height at 2 years of age.
  • Serum PFNA concentration was inversely associated with weight at 2 years of age.

Conclusions:

  • Serum PFC concentrations are inversely associated with height and weight in 2-year-old children.
  • Breastfeeding may contribute to early-life PFC exposure.
  • These findings highlight the potential impact of environmental contaminants on early childhood growth and development.

Keywords:
ChildEnvironmental exposureGrowthPerfluoroalkyl compounds

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