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Related Experiment Video

Updated: Feb 14, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2018.

Steven M Horwitz, Stephen M Ansell, Weiyun Z Ai

Journal of the National Comprehensive Cancer Network : JNCCN

|February 14, 2018

Summary

This summary is machine-generated.

Extranodal Natural Killer/T-cell Lymphomas (ENKL) are rare cancers. Current NCCN Guidelines provide recommendations for diagnosing and managing ENKL, as standard therapy is not yet established.

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Published on: September 12, 2025

Area of Science:

Hematology
Oncology
Pathology

Background:

Natural Killer (NK)/T-cell lymphomas represent a rare and distinct category of non-Hodgkin's lymphomas.
These lymphomas are predominantly extranodal, with the nasal type frequently affecting the upper aerodigestive tract.

Purpose of the Study:

To discuss the NCCN Guidelines recommendations for the diagnosis and management of extranodal NK/T-cell lymphomas (ENKL).
To address the lack of established standard therapy due to the rarity of ENKL and the absence of comparative randomized trials.

Main Methods:

Review of the NCCN Guidelines for T-Cell Lymphomas.
Synthesis of current recommendations for ENKL diagnosis and treatment.

Main Results:

The NCCN Guidelines offer a framework for managing ENKL patients.
Recommendations cover diagnostic approaches and therapeutic strategies for this rare malignancy.

Conclusions:

Standard therapy for ENKL is not yet established, highlighting the need for guideline-based management.
These insights provide crucial information for clinicians managing patients with extranodal NK/T-cell lymphomas.