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Updated: Feb 14, 2026

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis
04:36

Measurement of Tissue Oxygenation Using Near-Infrared Spectroscopy in Patients Undergoing Hemodialysis

Published on: October 2, 2020

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Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Lucie Kovarova1, Anna Valerianova1, Tereza Kmentova1

  • 1Third Department of Internal Medicine, Prague, Czech Republic.

Nephron
|February 14, 2018
PubMed

Insights

Cognitive impairment is common in hemodialysis (HD) patients. This study found that lower brain oxygenation (rSO2) is linked to poorer cognitive function in these individuals, suggesting a potential target for intervention.

Area of Science:

  • Nephrology
  • Neurology
  • Medical Diagnostics

Background:

  • High rates of cognitive impairment (CI) affect patients undergoing chronic hemodialysis (HD), with unclear pathophysiology.
  • Brain ischemia is a suspected cause, evidenced by decreased cerebral tissue oxygenation in HD patients.

Purpose of the Study:

  • To investigate the association between cognitive impairment and reduced cerebral oxygenation in chronic HD patients.
  • To identify other factors related to cerebral ischemia and cognitive decline in this population.

Main Methods:

  • A cross-sectional study included 39 chronic HD patients, with measurements taken pre-dialysis.
  • Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA).
  • Cerebral oxygenation was measured via regional saturation of oxygen (rSO2) using near-infrared spectroscopy; medical history, lab data, and handgrip strength were also analyzed.

Main Results:

  • Cognitively impaired patients exhibited significantly lower brain rSO2 compared to cognitively normal patients (48% vs. 57%, p=0.01).
  • Higher red cell distribution width (p=0.01) and lower handgrip strength (p<0.001) were also associated with CI.
  • The relationship between rSO2 and MoCA scores remained significant after adjusting for age and gender (p=0.007).

Conclusions:

  • Reduced brain oxygenation is demonstrably linked to poorer cognitive performance in patients on chronic HD.
  • Further research into the causes of cerebral ischemia in HD patients may help prevent cognitive decline.
Abstract

Keywords:
Cerebral oxygenationCognitive impairmentHemodialysisHemoglobin saturationNear-infrared spectroscopy

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