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Related Experiment Video

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Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
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Zinc and Skin Disorders.

Youichi Ogawa1, Manao Kinoshita2, Shinji Shimada3

  • 1Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan. yogawa@yamanashi.ac.jp.

Nutrients
|February 15, 2018
PubMed
Summary

Zinc (Zn) is crucial for skin health, impacting epidermis and dermis. Dysregulation of Zn transporters and Zn deficiency are linked to various skin disorders and delayed wound healing.

Keywords:
ATPLangerhans cellsacrodermatitis enteropathicanutritionskinzinc

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Area of Science:

  • Dermatology
  • Human Physiology
  • Molecular Biology

Background:

  • The skin, comprising epidermis, dermis, and subcutaneous tissue, is rich in zinc (Zn).
  • Zinc plays vital physiological roles within skin cells, facilitated by specific Zn transporters.
  • Disruptions in Zn homeostasis are implicated in numerous skin conditions.

Purpose of the Study:

  • To review the physiological functions of zinc and its transporters in skin cells.
  • To explore the association between Zn transporter mutations/dysregulation and skin manifestations.
  • To highlight the role of acquired zinc deficiency in dermatological diseases.

Main Methods:

  • Literature review of physiological functions of zinc and Zn transporters in skin.
  • Analysis of human disorders linked to genetic mutations in Zn transporters (ZIP4, ZIP13, ZnT2, ZnT1).
  • Examination of acquired zinc deficiency's impact on skin health and disease.

Main Results:

  • Mutations in ZIP4 (acrodermatitis enteropathica), ZIP13 (Ehlers-Danlos syndrome), ZnT2 (neonatal Zn deficiency), and ZnT1 (epidermodysplasia verruciformis) cause distinct skin disorders.
  • Acquired zinc deficiency is associated with nutritional deficiencies, alopecia, and impaired wound healing.
  • Zn transporters and overall zinc levels are critical for maintaining skin integrity and function.

Conclusions:

  • Mutations or dysregulation in zinc transporters are directly linked to specific inherited skin diseases.
  • Zinc deficiency, both inherited and acquired, significantly contributes to various dermatological conditions.
  • Understanding zinc's role is essential for diagnosing and managing skin manifestations related to Zn homeostasis disruption.